Open AccessTrained Immunity and Local Innate Immune Memory in the Lung
Author(s) -
Mihai G. Netea,
Leo A. B. Joosten
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.11.007
Subject(s) - biology , innate immune system , reprogramming , immunity , immunology , effector , heterologous , acquired immune system , epigenetics , myeloid cells , immune system , cell , genetics , gene
Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8 + lymphocytes initiating this process.
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