Boosting Immunity by Targeting Post-translational Prenylation of Small GTPases | Zendy

Caroline Robert | Zendy; Stéphan Vagner | Zendy

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Boosting Immunity by Targeting Post-translational Prenylation of Small GTPases

Author(s) -

Caroline Robert,

Stéphan Vagner

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.10.032

Subject(s) - biology , prenylation , boosting (machine learning) , gtpase , immunity , computational biology , small gtpase , microbiology and biotechnology , virology , immune system , signal transduction , genetics , biochemistry , artificial intelligence , enzyme , computer science

Diseases leading to immune activation and autoinflammatory phenotypes may provide a reservoir of potentially druggable pathways for optimizing immune adjuvants or boosting antitumor immune responses. Now, Xia et al. report that lipophilic statins or biphosphonates, targeting the mevalonate pathway, act as efficient vaccine adjuvants and synergize with anti-PD1 against cancer.

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