The Cellular and Molecular Basis for Planarian Regeneration | Zendy

Peter W. Reddien | Zendy

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The Cellular and Molecular Basis for Planarian Regeneration

Author(s) -

Peter W. Reddien

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.09.021

Subject(s) - planarian , biology , regeneration (biology) , stem cell , induced pluripotent stem cell , microbiology and biotechnology , population , evolutionary biology , genetics , embryonic stem cell , gene , demography , sociology

Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats. A stem cell population (neoblasts) generates new cells and is comprised of pluripotent stem cells (cNeoblasts) and fate-specified cells (specialized neoblasts). Positional information is constitutively active and harbored primarily in muscle, where it acts to guide stem cell-mediated tissue turnover and regeneration. I describe here a model in which positional information and stem cells combine to enable regeneration.

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