Open AccessChromatin Domains Go on Repeat in Disease
Author(s) -
Benoit G. Bruneau,
Elphège P. Nora
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.08.068
Subject(s) - biology , chromatin , genetics , genome , ctcf , evolutionary biology , gene , enhancer , gene expression
TAD boundaries are insulators of genomic neighborhoods. In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntington's disease.
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