Open AccessLa Dolce Vita of Neurexin: Synaptic Partnerships through Glycosaminoglycans
Author(s) -
K. Suzuki,
Michisuke Yuzaki
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.08.052
Subject(s) - neurexin , biology , heparan sulfate , microbiology and biotechnology , neuroscience , glycosaminoglycan , biochemistry , receptor , postsynaptic potential
Various neurexin transcripts are thought to serve as presynaptic "hub" molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins.
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