Open AccessTuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1
Author(s) -
Haiyang Yu,
Don W. Cleveland
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.08.035
Subject(s) - biology , neuroinflammation , apoptosis , microbiology and biotechnology , neuroscience , cancer research , bioinformatics , inflammation , genetics , immunology
Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.
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