The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment | Zendy

Samuel F. Bakhoum | Zendy; Lewis C. Cantley | Zendy

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The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

Author(s) -

Samuel F. Bakhoum,

Lewis C. Cantley

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.08.027

Subject(s) - biology , chromosome instability , tumor microenvironment , genome instability , crosstalk , cancer research , immune system , mitosis , cancer , chromosome , genetics , gene , microbiology and biotechnology , dna , dna damage , physics , optics

Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.

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