Open AccessFreeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead
Author(s) -
Kiran Raosaheb Patil,
Markus Ralser
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.08.024
Subject(s) - biology , saccharomyces cerevisiae , yeast , metabolic engineering , eukaryotic cell , metabolism , computational biology , biochemistry , gene
Synthetically re-designing eukaryotic metabolism has proven immensely challenging, raising the question of whether evolution has metabolically hardwired eukaryotic cells. Yu et al. now report that, through orchestrating multiple genetic changes and laboratory evolution, Saccharomyces metabolism can be reprogrammed from its evolutionary objective of producing ethanol to produce large amounts of free fatty acids.
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