Open AccessMetabolic Frugality Marks Cancer Cells for Immune Targeting
Author(s) -
Lucas B. Sullivan
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.08.023
Subject(s) - biology , cancer cell , cancer , cancer immunotherapy , cancer research , immune system , cell growth , cell cycle , immunotherapy , cell , microbiology and biotechnology , immunology , biochemistry , genetics
Altered cell metabolism is ubiquitous in cancer cells; however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer cells for recognition by immunotherapy.
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