PP1 Phosphatase Complexes: Undruggable No Longer | Zendy

Paola Vagnarelli | Zendy; Dario R. Alessi | Zendy

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PP1 Phosphatase Complexes: Undruggable No Longer

Author(s) -

Paola Vagnarelli,

Dario R. Alessi

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.08.007

Subject(s) - biology , phosphatase , phosphorylation , serine , protein phosphatase 1 , protein phosphatase 2 , threonine , kinase , protein subunit , neurodegeneration , protein serine threonine kinases , microbiology and biotechnology , biochemistry , akt3 , protein kinase a , disease , gene , medicine , pathology

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

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