Open AccessEnhancing Therapy: It’s about Time
Author(s) -
Myles Brown
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.07.037
Subject(s) - biology , circadian rhythm , lipid metabolism , obesity , enhancer , bioinformatics , endocrinology , pharmacology , physiology , medicine , gene , genetics , transcription factor
How diet and obesity impact diurnal changes in physiology remains unclear. In this issue of Cell, Guan et al. report that diet-induced obesity modulates the activity of circadian gene enhancers including those regulating lipid metabolism and show that the efficacy of lipid-lowering drugs depends on the time of administration.
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