Open AccessKrebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers
Author(s) -
Michael P. Murphy,
Luke O'neill
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.07.030
Subject(s) - biology , signal (programming language) , transducer , microbiology and biotechnology , computational biology , acoustics , computer science , physics , programming language
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
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