Open AccessViral Teamwork Pushes CRISPR to the Breaking Point
Author(s) -
Philip M. Nussenzweig,
Luciano A. Marraffini
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.07.025
Subject(s) - crispr , biology , virology , immune system , computational biology , trans activating crrna , genome editing , genetics , gene
Viruses have evolved inhibitors to counteract the CRISPR immune response, but they are not fully potent and need some time to be expressed after the beginning of infection. In this issue of Cell, Borges et al. and Landsberger et al. show that sequential infection gradually immunosuppresses the host to allow effective CRISPR inhibition.
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