Open AccessThe Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis
Author(s) -
Yoku Hayakawa,
Timothy C. Wang
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.06.037
Subject(s) - biology , innate lymphoid cell , tuft , immune system , innate immune system , microbiology and biotechnology , immunology , homeostasis , materials science , composite material
The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.
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