Open AccessIncreasing T Cell Versatility with SUPRA CARs
Author(s) -
Yvonne Y. Chen
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.05.030
Subject(s) - chimeric antigen receptor , cytokine release syndrome , antigen , adoptive cell transfer , cell therapy , cd19 , cancer research , biology , cancer , t cell receptor , immunotherapy , immunology , t cell , medicine , cell , immune system , genetics
Chimeric antigen receptor (CAR) T cells offer a promising treatment option for advanced cancers resistant to standard therapy. Here, Cho et al. report a split-CAR design that enables the engineering of multi-feature CAR-T cells, aiming to address current challenges limiting the safety and efficacy of CAR-T cells for cancer treatment.
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