Open AccessA “Counter-Enhancer” in Tumor Suppression
Author(s) -
Francesco P. Marchese,
Maite Huarte
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.05.023
Subject(s) - biology , enhancer , pvt1 , suppressor , genetics , gene , dna , genome , regulatory sequence , promoter , regulation of gene expression , computational biology , microbiology and biotechnology , cancer research , gene expression , long non coding rna , rna
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom