Open AccessBetter Together: A Hybrid Amyloid Signals Necroptosis
Author(s) -
Dan Li,
Cong Liu
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.04.030
Subject(s) - biology , necroptosis , amyloid (mycology) , computational biology , neuroscience , microbiology and biotechnology , genetics , programmed cell death , apoptosis , botany
A new solid-state NMR study determines the high-resolution hetero-amyloid structure of the RIPK1-RIPK3 signaling complex that is involved in mediating necroptosis. The structure demonstrates specific formation of hetero-amyloids over homo-amyloids and the structural basis for a functional amyloid to act as a platform to recruit and activate downstream partners in intracellular signaling.
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