Open AccessA Mechanosensitive GPCR that Detects the Bloody Force
Author(s) -
Adam J. Iliff,
X.Z. Shawn Xu
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.04.001
Subject(s) - mechanosensitive channels , mechanotransduction , mechanoreceptor , biology , mechanosensation , piezo1 , neuroscience , ion channel , anatomy , sensory system , microbiology and biotechnology , receptor , biochemistry
Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.
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