The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress | Zendy

Moriel Zelikowsky | Zendy; May Hui | Zendy; Tomomi Karigo | Zendy; Andrea Choe | Zendy; Bin Yang | Zendy; Mario R. Blanco | Zendy; Keith Beadle | Zendy; Viviana Gradinaru | Zendy; Benjamin E. Deverman | Zendy; David J. Anderson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress

Author(s) -

Moriel Zelikowsky,

May Hui,

Tomomi Karigo,

Andrea Choe,

Bin Yang,

Mario R. Blanco,

Keith Beadle,

Viviana Gradinaru,

Benjamin E. Deverman,

David J. Anderson

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.03.037

Subject(s) - neuropeptide , biology , downregulation and upregulation , social isolation , aggression , neuroscience , antagonist , chronic stress , brain function , medicine , endocrinology , receptor , psychology , developmental psychology , biochemistry , gene , psychotherapist

Chronic social isolation causes severe psychological effects in humans, but their neural bases remain poorly understood. 2 weeks (but not 24 hr) of social isolation stress (SIS) caused multiple behavioral changes in mice and induced brain-wide upregulation of the neuropeptide tachykinin 2 (Tac2)/neurokinin B (NkB). Systemic administration of an Nk3R antagonist prevented virtually all of the behavioral effects of chronic SIS. Conversely, enhancing NkB expression and release phenocopied SIS in group-housed mice, promoting aggression and converting stimulus-locked defensive behaviors to persistent responses. Multiplexed analysis of Tac2/NkB function in multiple brain areas revealed dissociable, region-specific requirements for both the peptide and its receptor in different SIS-induced behavioral changes. Thus, Tac2 coordinates a pleiotropic brain state caused by SIS via a distributed mode of action. These data reveal the profound effects of prolonged social isolation on brain chemistry and function and suggest potential new therapeutic applications for Nk3R antagonists.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research