Open AccessA Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance
Author(s) -
Joerg Huelsken,
Douglas Hanahan
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.01.028
Subject(s) - biology , cancer research , cancer , cancer therapy , resistance (ecology) , microbiology and biotechnology , genetics , ecology
While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates elucidation of roles among ostensibly distinctive fibroblastic states. In this issue of Cell, Su et al. characterize a new pro-tumorigenic cancer-associated fibroblast subset mediating chemoresistance defined and driven by a novel signaling pathway.
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