Open AccessBrother’s Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis
Author(s) -
Yi-Jang Lin,
Kevin M. Haigis
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.01.019
Subject(s) - biology , mutant , carcinogenesis , wild type , brother , genetics , limit (mathematics) , microbiology and biotechnology , gene , mathematical analysis , mathematics , sociology , anthropology
K-Ras is the undisputed champion of oncogenes, yet our ability to interfere with its oncogenic function is hampered by insufficient mechanistic understanding. In this issue of Cell, Ambrogio and colleagues connect the ability of K-Ras to dimerize to the ability of wild-type K-Ras to limit the oncogenic properties of the mutant.
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