Open AccessAn Element of Life
Author(s) -
Douglas R. Green
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.01.003
Subject(s) - selenocysteine , selenoprotein , selenium , gpx1 , gpx4 , glutathione peroxidase , biology , function (biology) , peroxidase , selenoprotein p , biochemistry , gpx6 , enzyme , genetics , glutathione , chemistry , cysteine , organic chemistry
While it has been known for decades that the essential function of selenium was in the form of its incorporation as selenocysteine into selenoproteins-including the enzyme glutathione peroxidase-4-now, Ingold et al. (2018) reveal the precise role of selenolate-based catalysis by this enzyme.
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