On the Design of Combination Cancer Therapy | Zendy

James H. Doroshow | Zendy; Richard Simon | Zendy

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On the Design of Combination Cancer Therapy

Author(s) -

James H. Doroshow,

Richard Simon

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.11.035

Subject(s) - biology , cancer , cancer therapy , combination therapy , clinical trial , computational biology , drug , human cell , bioinformatics , pharmacology , cell culture , genetics

Combination therapy programs are the hallmark of the successful treatment of all forms of human malignancies. In this issue of Cell, Palmer and Sorger present data suggesting that cell culture results indicative of synergistic anticancer drug interactions rarely translate clinically and that the results of combination therapies in mouse models or human clinical trials, even if successful, are best explained by the independent activities of the individually administered drugs.

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