Open AccessRisky Business: The Circuits that Impact Stress-Induced Decision-Making
Author(s) -
Amy F.T. Arnsten,
Daeyeol Lee,
Christopher Pittenger
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.11.004
Subject(s) - biology , stress (linguistics) , microbiology and biotechnology , philosophy , linguistics
How does stress promote risky decision-making? Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensitive to potential losses. This may help explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette syndrome.
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