Open AccessTuning Biased GPCR Signaling for Physiological Gain
Author(s) -
Skylar M. Spangler,
Michael R. Bruchas
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.10.046
Subject(s) - biology , g protein coupled receptor , opiate , signal transduction , receptor , pharmacology , microbiology and biotechnology , genetics
Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.
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