Cancer Evolution: No Room for Negative Selection | Zendy

Samuel F. Bakhoum | Zendy; Dan A. Landau | Zendy

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Cancer Evolution: No Room for Negative Selection

Author(s) -

Samuel F. Bakhoum,

Dan A. Landau

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.10.039

Subject(s) - biology , somatic hypermutation , selection (genetic algorithm) , cancer , somatic evolution in cancer , negative selection , genetics , somatic cell , evolutionary biology , positive selection , genomics , computational biology , mutation , genome , gene , artificial intelligence , computer science , b cell , antibody

In this issue of Cell, Martincorena et al. and Campbell et al. interrogated the selection dynamics during tumor evolution using large-scale genomics datasets. They found that somatic mutations in cancer are largely neutral, highlighting a near-complete absence of negative selection. Neutral evolution enables tolerance of hypermutation, which defines a surprisingly large fraction of adult cancer.

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