Open AccessA Missing Link to Vitamin B12 Metabolism
Author(s) -
Michael A. Reid,
Jihye Paik,
Jason W. Locasale
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.10.030
Subject(s) - biology , vitamin b12 , function (biology) , metabolism , allele , population , metabolite , genetics , gene , biochemistry , demography , sociology
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B 12 levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B 12 metabolism and the immunomodulatory metabolite, itaconate.
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