Friends in Low Places: Intestinal Commensals Limit Colitis through Molecular Mimicry | Zendy

D. Garrett Brown | Zendy; June L. Round | Zendy

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Friends in Low Places: Intestinal Commensals Limit Colitis through Molecular Mimicry

Author(s) -

D. Garrett Brown,

June L. Round

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.09.053

Subject(s) - biology , mimicry , molecular mimicry , commensalism , bacteroides , disease , epitope , mechanism (biology) , immunology , inflammatory bowel disease , colitis , inflammation , microbiology and biotechnology , immune system , bacteria , antigen , zoology , genetics , medicine , philosophy , epistemology , pathology

Inflammatory bowel disease is thought to arise from inappropriate inflammation to gut bacteria, yet mechanisms preventing these responses remain elusive. In this issue of Cell, Nanjundappa et al. report that Bacteroides share an epitope with a pancreas-specific peptide that induces protective CD8+ T cells, identifying molecular mimicry as a mechanism to enforce tolerance in the gut.

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