Open AccessGuardians of the ERAD Galaxy
Author(s) -
Zhihao Sun,
Jeffrey L. Brodsky
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.09.023
Subject(s) - endoplasmic reticulum associated protein degradation , endoplasmic reticulum , protein folding , biology , microbiology and biotechnology , secretory pathway , unfolded protein response , biochemistry , golgi apparatus
The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.
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