Open AccessCrowd Control: E7 Conservation Is the Key to Cancer
Author(s) -
Elizabeth White,
Karl Münger
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.08.033
Subject(s) - biology , carcinogenesis , genotype , cancer , human papillomavirus , cancer research , cervical cancer , genetics , virology , gene , medicine
Several human papillomavirus type 16 (HPV16) oncoproteins contribute to cellular transformation in vitro. In this issue of Cell, Mirabello and colleagues use high-throughput sequencing data to assess the diversity of HPV16 isolates from human patients. These data suggest that the E7 oncoprotein is the fundamental contributor to in vivo carcinogenesis.
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