Open AccessCancer Evolution Constrained by the Immune Microenvironment
Author(s) -
Nicholas McGranahan,
Charles Swanton
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.08.012
Subject(s) - biology , cancer , tumor microenvironment , serous carcinoma , ovarian cancer , immunotherapy , immune system , cancer research , immunology , genetics
Tumor development is a Darwinian evolutionary process, involving the interplay between cancer subclones and the local immune microenvironment. These complex interactions are highlighted in this issue of Cell by the results from Jiménez-Sánchez et al. of a deep analysis of one patient with advanced serous carcinoma of the ovary.
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