Open AccessReprogramming Enhancers to Drive Metastasis
Author(s) -
Raúl Mostoslavsky,
Nabeel Bardeesy
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.08.010
Subject(s) - reprogramming , biology , enhancer , metastasis , cancer research , pdx1 , foxa1 , pancreatic cancer , stem cell , microbiology and biotechnology , cell , cancer , transcription factor , genetics , gene
Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom