Open AccessTranscription-Replication Conflicts: Orientation Matters
Author(s) -
Yea-Lih Lin,
Philippe Pasero
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.07.040
Subject(s) - biology , genome instability , transcription (linguistics) , dna replication , dna , genetics , gene , rna , rna polymerase , dna damage , linguistics , philosophy
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.
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