Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease | Zendy

Justin M. Richner | Zendy; Brett W. Jagger | Zendy; Chao Shan | Zendy; Camila R. Fontes-Garfias | Zendy; Kimberly A. Dowd | Zendy; Bin Cao | Zendy; Sunny Himansu | Zendy; Elizabeth A. Caine | Zendy; Bruno Tardelli Diniz Nunes | Zendy; Daniele Barbosa de Almeida Medeiros | Zendy; Antonio E. Muruato | Zendy; Bryant M. Foreman | Zendy; Huanle Luo | Zendy; Tian Wang | Zendy; Alan D.T. Barrett | Zendy; Scott C. Weaver | Zendy; Pedro Fernando da Costa Vasconcelos | Zendy; Shannan L. Rossi | Zendy; Giuseppe Ciaramella | Zendy; Indira U. Mysorekar | Zendy; Theodore C. Pierson | Zendy; PeiYong Shi | Zendy; Michael Diamond | Zendy

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Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Author(s) -

Justin M. Richner,

Brett W. Jagger,

Chao Shan,

Camila R. Fontes-Garfias,

Kimberly A. Dowd,

Bin Cao,

Sunny Himansu,

Elizabeth A. Caine,

Bruno Tardelli Diniz Nunes,

Daniele Barbosa de Almeida Medeiros,

Antonio E. Muruato,

Bryant M. Foreman,

Huanle Luo,

Tian Wang,

Alan D.T. Barrett,

Scott C. Weaver,

Pedro Fernando da Costa Vasconcelos,

Shannan L. Rossi,

Giuseppe Ciaramella,

Indira U. Mysorekar,

Theodore C. Pierson,

PeiYong Shi,

Michael Diamond

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.06.040

Subject(s) - zika virus , biology , virology , fetus , heterologous , virus , immunology , attenuated vaccine , microcephaly , pregnancy , gene , virulence , genetics

The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability to protect against transmission to the fetus. Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 (E6) and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise. As modified mRNA and live-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further development in humans to prevent congenital ZIKV syndrome is warranted.

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