Friction at the BAR Leads to Membrane Breakup | Zendy

Kranthi K. Mandadapu | Zendy; James H. Hurley | Zendy

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Friction at the BAR Leads to Membrane Breakup

Author(s) -

Kranthi K. Mandadapu,

James H. Hurley

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.06.027

Subject(s) - dynamin , biology , endocytic cycle , endosome , microbiology and biotechnology , vesicle , lipid bilayer fusion , membrane , cell membrane , lipid bilayer , endocytosis , fission , biophysics , cell , biochemistry , physics , intracellular , quantum mechanics , neutron

A long-standing question in cell biology is how endocytic vesicles and tubules detach from the plasma membrane in the absence of constriction by dynamin. In this issue of Cell, Simunovic et al. describe an elegant biophysical model in which friction between lipids and BAR-domain proteins drives the scission of elongating membrane tubules.

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