SnapShot: Phosphoregulation of Mitosis | Zendy

Andrew Burgess | Zendy; Jenny Vuong | Zendy; Samuel Rogers | Zendy; Marcos Malumbres | Zendy; Séan O’Donoghue | Zendy

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SnapShot: Phosphoregulation of Mitosis

Author(s) -

Andrew Burgess,

Jenny Vuong,

Samuel Rogers,

Marcos Malumbres,

Séan O’Donoghue

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.06.003

Subject(s) - biology , snapshot (computer storage) , mitosis , microbiology and biotechnology , cell division , computational biology , mitotic exit , genetics , cell , spindle apparatus , computer science , operating system

During mitosis, a cell divides its duplicated genome into two identical daughter cells. This process must occur without errors to prevent proliferative diseases (e.g., cancer). A key mechanism controlling mitosis is the precise timing of more than 32,000 phosphorylation and dephosphorylation events by a network of kinases and counterbalancing phosphatases. The identity, magnitude, and temporal regulation of these events have emerged recently, largely from advances in mass spectrometry. Here, we show phosphoevents currently believed to be key regulators of mitosis. For an animated version of this SnapShot, please see http://www.cell.com/cell/enhanced/odonoghue2.

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