Open AccessMicrobiome and Longevity: Gut Microbes Send Signals to Host Mitochondria
Author(s) -
Jan Gruber,
Brian K. Kennedy
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.05.048
Subject(s) - biology , longevity , microbiome , host (biology) , mitochondrion , gut bacteria , gut microbiome , disease , caenorhabditis elegans , evolutionary biology , genetics , gene , medicine , pathology
The microbiome has emerged as a major determinant of the functioning of host organisms, affecting both health and disease. Here, Han et al. use the workhorse of aging research, C. elegans, to identify specific mechanisms by which gut bacteria influence mitochondrial dynamics and aging, a first step toward analogous manipulations to modulate human aging.
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