Open AccessJust a Spoonful of Sugar Helps the Tolerance Go Up
Author(s) -
Alexander V. Chervonsky
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.05.040
Subject(s) - biology , sugar , resistance (ecology) , insulin resistance , ferritin , gluconeogenesis , ecology , biochemistry , microbiology and biotechnology , insulin , metabolism
Survival of deleterious infections depends significantly on how much stress the affected organism can tolerate. In this issue, Weis et al. find that mice can survive sepsis by maintaining normoglycemia through ferritin's capacity to inactivate Fe 2+ ions that otherwise induce free radicals impacting gluconeogenesis in the liver.
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