Open AccessCurbing Tregs’ (Lack of) Enthusiasm
Author(s) -
Taha Merghoub,
Jedd D. Wolchok
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.05.027
Subject(s) - biology , enthusiasm , immunity , interferon gamma , treg cell , tumor microenvironment , immunology , microbiology and biotechnology , cancer research , immune system , t cell , il 2 receptor , psychology , social psychology
In this issue, Overacre-Delgoffe et al. show that interferon gamma production by a subset of regulatory T cells in the tumor microenvironment triggers Treg instability locally and restores anti-tumor immunity.
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