Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities | Zendy

Roel Nusse | Zendy; Hans Clevers | Zendy

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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Author(s) -

Roel Nusse,

Hans Clevers

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.05.016

Subject(s) - wnt signaling pathway , biology , lrp5 , signal transduction , stem cell , lrp6 , cancer research , regulator , microbiology and biotechnology , genetics , gene

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

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