Open AccessDon’t Stop Re-healin’! Cancer as an Ongoing Stem Cell Affair
Author(s) -
Samuel P. Rowbotham,
Carla F. Kim
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2017.04.030
Subject(s) - biology , stem cell , cancer stem cell , cancer , genetics , cancer research
Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.
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