Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression | Zendy

Bas van Steensel | Zendy; Andrew S. Belmont | Zendy

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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression

Author(s) -

Bas van Steensel,

Andrew S. Belmont

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.04.022

Subject(s) - biology , heterochromatin , genetics , psychological repression , gene , chromosome , microbiology and biotechnology , evolutionary biology , gene expression

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.

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