An Immune Atlas of Clear Cell Renal Cell Carcinoma | Zendy

Stéphane Chevrier | Zendy; Jacob Levine | Zendy; Vito Riccardo Tomaso Zanotelli | Zendy; Karīna Siliņa | Zendy; Daniel Schulz | Zendy; Marina Bacac | Zendy; Carola H. Ries | Zendy; Laurie Ailles | Zendy; Michael Alexander Spencer Jewett | Zendy; Holger Moch | Zendy; Maries van den Broek | Zendy; Christian Beisel | Zendy; Michael Stadler | Zendy; Craig Gedye | Zendy; Bernhard Reis | Zendy; Dana Pe’er | Zendy; Bernd Bodenmiller | Zendy

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An Immune Atlas of Clear Cell Renal Cell Carcinoma

Author(s) -

Stéphane Chevrier,

Jacob Levine,

Vito Riccardo Tomaso Zanotelli,

Karīna Siliņa,

Daniel Schulz,

Marina Bacac,

Carola H. Ries,

Laurie Ailles,

Michael Alexander Spencer Jewett,

Holger Moch,

Maries van den Broek,

Christian Beisel,

Michael Stadler,

Craig Gedye,

Bernhard Reis,

Dana Pe’er,

Bernd Bodenmiller

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.04.016

Subject(s) - biology , mass cytometry , immune system , tumor microenvironment , immunotherapy , clear cell renal cell carcinoma , phenotype , cancer research , cancer immunotherapy , renal cell carcinoma , cell , immunology , pathology , medicine , biochemistry , genetics , gene

Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls. In 3.5 million measured cells, we identified 17 tumor-associated macrophage phenotypes, 22 T cell phenotypes, and a distinct immune composition correlated with progression-free survival, thereby presenting an in-depth human atlas of the immune tumor microenvironment in this disease. This study revealed potential biomarkers and targets for immunotherapy development and validated tools that can be used for immune profiling of other tumor types.

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