Metabolic Instruction of Immunity | Zendy

Michael D. Buck | Zendy; Ryan Sowell | Zendy; Susan M. Kaech | Zendy; Erika L. Pearce | Zendy

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Metabolic Instruction of Immunity

Author(s) -

Michael D. Buck,

Ryan Sowell,

Susan M. Kaech,

Erika L. Pearce

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.04.004

Subject(s) - biology , immunity , immunology , immune system

Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.

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