Translating Germline Cancer Risk into Precision Prevention | Zendy

Matthew B. Yurgelun | Zendy; Georgia ChenevixTrench | Zendy; Scott M. Lippman | Zendy

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Translating Germline Cancer Risk into Precision Prevention

Author(s) -

Matthew B. Yurgelun,

Georgia ChenevixTrench,

Scott M. Lippman

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.01.031

Subject(s) - biology , germline , precision medicine , cancer , cancer prevention , germline mutation , bioinformatics , computational biology , mutation , genetics , gene

Study of the biology of tumors caused by germline mutations has led to recent paradigm-changing therapy and is driving precision prevention efforts, including immune oncology and early detection research. Here, we explore recent biologic advances that are redefining the spectrum of cancers linked to various hereditary predisposition syndromes and can be leveraged to improve personalized risk assessment and develop novel interventions to prevent or intercept cancer.

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