The Long Tail of mRNA Regulation | Zendy

Rachel  Green | Zendy; Ian  Macrae | Zendy; Christine  Mayr | Zendy

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The Long Tail of mRNA Regulation

Author(s) -

Rachel Green,

Ian Macrae,

Christine Mayr

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.01.015

Subject(s) - biology , conversation , untranslated region , messenger rna , three prime untranslated region , microrna , coding region , gene , rna binding protein , rna , function (biology) , genetics , post transcriptional regulation , gene expression , computational biology , microbiology and biotechnology , sociology , communication

Long stretches of RNA trail after the coding region in most eukaryotic mRNAs. These 3' untranslated regions (3' UTRs) hold the key for many aspects of regulated gene expression, influencing mRNA stability, protein synthesis, and ultimately protein function. Lara Szewczak asked Rachel Green, Ian Macrae, and Christine Mayr about how dynamic regulation by proteins and microRNAs works within 3' UTRs. An annotated excerpt of the conversation appears below, and the full conversation is available with the article online.

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