30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology | Zendy

Qian Zhang | Zendy; Michael J. Lenardo | Zendy; David Baltimore | Zendy

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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

Author(s) -

Qian Zhang,

Michael J. Lenardo,

David Baltimore

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.12.012

Subject(s) - biology , relevance (law) , nf κb , computational biology , genetics , signal transduction , political science , law

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.

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