Open AccessThe Interfaces of Genetic Conflict Are Hot Spots for Innovation
Author(s) -
Joshua A. Carter,
Connor Hoffman,
Blake Wiedenheft
Publication year - 2017
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.12.007
Subject(s) - biology , cas9 , crispr , genome editing , computational biology , endonuclease , function (biology) , dna , rna , microbiology and biotechnology , genetics , gene
RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for the Cas9 scalpel.
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