Harvesting Benefits from Cannabinoids

With the ongoing liberalization of cannabis laws in many parts of the United States that are decriminalizing its recreational and/or medical use, there is much discussion about the benefits of cannabinoids and how to mitigate potential negative societal repercussions of increased access to them. At risk of being overshadowed amidst this debate is the fascinating biology coming to light about how cannabinoids mediate their effects, including the crystal structures of human CB1 cannabinoid receptors (Hua et al., 2016; Shao et al., 2016), and surprising insights about where in the cell they act (Herbert-Chatelain et al., 2016; Younts et al., 2016).