Open AccessMetformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging
Author(s) -
Jorge Iván Castillo-Quan,
T. Keith Blackwell
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.11.058
Subject(s) - metformin , biology , mtorc1 , cell growth , cancer , cell , cancer research , microbiology and biotechnology , diabetes mellitus , pharmacology , endocrinology , pi3k/akt/mtor pathway , signal transduction , genetics
In this issue of Cell, Wu et al. employed C. elegans and human cell experiments to identify a pathway through which metformin increases lifespan and inhibits growth. A key transcriptional target, ACAD10, is activated when metformin induces nuclear exclusion of the GTPase RagC, thereby inhibiting mTORC1 through an unexpected mechanism.
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